MagIC's Magnets

We are leveraging giant magnetoresistance (GMR) to advance molecular diagnostics. Our GMR biosensors are the magic behind ultra-high sensitivity and multiplex capabilities.

Novel GMR Biosensor Detection Method

GMR Biosensors

Giant Magnetoresistance

64-sensor array

Substrate for multiplexed DNA hybridization

Similar to DNA microarrays

Local proximity magnetic sensor

This first-of-its-kind GMR technology enables an all-in-one workflow of performing multiplexed PCR and DNA detection on a single GMR sensor chip.

Elaine Ng, PhD, CSO Magic Lifescience

What is Giant Magnetoresistance?

What is Giant Magnetoresistance?

  • Quantum mechanical effect unique to layered
    thin films
  • Electrical resistance of a GMR sensor is
    dependent on magnetic alignment of thin film
  • GMR sensors detect minute changes in local
    magnetic field when magnetic nanoparticles
    (MNPs) bind (see animation)
  • GMR signal is quantitative with respect to
    number of MNPs bound to nanosensor
  • Low limits of detection (50 aM) and high
    dynamic range (6 logs)

How are GMR sensors made?

Modern microelectromechanical systems (MEMS) fabrication technology

Easy to make with high yield and low cost

Compatible with standard integrated circuit (IC) fabrication

Processor and sensors can be miniaturized and integrated on one chip

Why GMR Technology for Molecular Diagnostics?

Foregoing Fluorescence

Nano-materials, Big Solutions